Relationship between allostatic load and clinical outcomes in youth at ultra-high risk for psychosis in the NEURAPRO study

Berger, Maximus, Lavoie, Suzie, McGorry, Patrick D., Nelson, Barnaby, Markulev, Connie, Yuen, Hok-Pan, Schaefer, Miriam, Sarnyai, Zoltán, and Amminger, G. Paul (2020) Relationship between allostatic load and clinical outcomes in youth at ultra-high risk for psychosis in the NEURAPRO study. Schizophrenia Research, 226. pp. 38-43.

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Individuals at ultra-high risk (UHR) for psychosis have an elevated risk of developing psychosis and other psychiatric outcomes. Risk biomarkers can assist in delineating individual risk and allow better prediction of longer-term outcomes. The aim of the present study was to examine if allostatic load (AL), a multisystem index of neuroendocrine, cardiovascular, immune and metabolic dysregulation, is associated with clinical outcomes in youth at UHR for psychosis.

AL was measured in 106 participants of the NEURAPRO study (n = 70 female, n = 36 male; mean age 17.21, SD 2.37), a multicentre randomized-controlled trial of long-chain omega-3 polyunsaturated fatty acids versus placebo in people at UHR for psychosis. Psychiatric symptoms and social and occupational functioning were assessed at baseline and 6 and 12 months after study intake. Multivariate linear and logistic regression models were used to test the relationship between AL and clinical outcomes.

High AL at baseline was associated with poor social and occupational functioning at 6 months (β = −0.224, p = 0.025) and with more severe manic symptoms at 6 months (β = 0.207, p = 0.026), taking into account relevant covariates including age and smoking status. No significant associations were observed at the 12-month follow-up assessment or with any other clinical outcome measures.

Our data provide initial evidence for a link between AL and impaired functioning in individuals at UHR for psychosis. Further studies are needed to evaluate AL as a potential predictor of early treatment response.

Item ID: 57138
Item Type: Article (Research - C1)
ISSN: 1573-2509
Keywords: allostatic load; ultra-high risk; psychosis; biomarker; stress; inflammation
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Copyright Information: Copyright © 2018 Elsevier B.V. All rights reserved.
Additional Information:

A version of this publication was included as Chapter 4 of the following PhD thesis: Berger, Maximus (2018) Biological endophenotypes of prodromal psychosis and depression. PhD thesis, James Cook University, which is available Open Access in ResearchOnline@JCU. Please see the Related URLs for access.

Funders: James Cook University (JCU)
Projects and Grants: JCU Higher Degree Research Enhancement Funding Scheme
Date Deposited: 18 Feb 2019 22:52
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320903 Central nervous system @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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