The elevated plus maze test for measuring anxiety-like behavior in rodents

Kraeuter, Ann-Katrin, Guest, Paul C., and Sarnyai, Zoltan (2019) The elevated plus maze test for measuring anxiety-like behavior in rodents. In: Guest, Paul C., (ed.) Pre-Clinical Models: techniques and protocols. Methods in Molecular Biology, 1916 . Springer, New York, NY, USA, pp. 69-74.

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Abstract

The elevated plus maze test is used to measure anxiety-like behavior in rodents. It can be used to gain insight into conditions such as posttraumatic stress disorder (PTSD) and other conditions marked by anxious behavior. It can also be used as a component in screening of novel compounds for anxiolytic properties. This model is based on aversion to open spaces, which is seen as the animal spending more time in the enclosed arms of the maze. This chapter describes the steps necessary for setting up and conducting the test, along with interpretation of the results.

Item ID: 57125
Item Type: Book Chapter (Scholarly Work)
ISBN: 978-1-4939-8993-5
Keywords: Behavior, Anxiety, Rodent, Mouse, Elevated plus maze, Anxiolytic
Copyright Information: © Springer Science+Business Media, LLC, part of Springer Nature 2019
Date Deposited: 26 Feb 2020 03:50
FoR Codes: 17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1701 Psychology > 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 60%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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