Case-fatality ratio of blood culture–confirmed typhoid fever in Dhaka, Bangladesh

Yu, Alexander T., Amin, Nuhu, Rahman, Muhammad Waliur, Gurley, Emily S., Rahman, Kazi Mizanur, and Luby, Stephen P. (2018) Case-fatality ratio of blood culture–confirmed typhoid fever in Dhaka, Bangladesh. Journal of Infectious Diseases, 218 (Suppl 4). S222-S226.

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With impending rollout of new conjugate typhoid vaccines, better estimates of typhoid case-fatality ratio are needed for countries to set priorities for public health programs. We enrolled 1425 patients of all ages with blood culture–confirmed Salmonella Typhi from laboratory networks serving inpatients and outpatients in Dhaka, Bangladesh. Participants were asked about symptoms and complications including death experienced over a median 3-month period following blood culture diagnosis. Four fatal cases were identified (case-fatality ratio of 0.3% [95% confidence interval, .05%–.55%]). Applying this case-fatality ratio to global typhoid burden estimates would reduce deaths by 70%.

Item ID: 57057
Item Type: Article (Research - C1)
ISSN: 1537-6613
Keywords: typhoid, case-fatality, Bangladesh
Copyright Information: © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Funders: Centers for Disease Control (CDC)
Projects and Grants: CDC grant number 081126
Date Deposited: 11 Feb 2019 22:33
FoR Codes: 42 HEALTH SCIENCES > 4202 Epidemiology > 420299 Epidemiology not elsewhere classified @ 50%
42 HEALTH SCIENCES > 4206 Public health > 420699 Public health not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 50%
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