Evidence of exposure and human seroconversion during an outbreak of avian influenza A(H5N1) among poultry in Cameroon

Monamele, Chavely Gwladys, Y., Phalla, Karlsson, Erik Albert, Vernet, Marie-Astrid, Wade, Abel, Okomo, Marie-Claire Assoumou, Abah, Aristide Stéphane Abah, Yann, Sokhoun, Etoundi, Georges Alain Mballa, Mohamadou, Njankouo Ripa, Feussom, Jean-Marc, Horm, Sreyviseth, Horwood, Paul Francis, Ly, Sowath, Njouom, Richard, and Dussart, Philippe (2019) Evidence of exposure and human seroconversion during an outbreak of avian influenza A(H5N1) among poultry in Cameroon. Emerging Microbes & Infections, 8 (1). pp. 186-196.

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Abstract

From May 2016 to March 2017, 22 poultry outbreaks of avian influenza A(H5N1) were reported in Cameroon, mainly in poultry farms and live bird markets. No human cases were reported. In this study, we sought to describe the 2016 A(H5N1) outbreak strain and to investigate the risk of infection in exposed individuals. We find that highly pathogenic influenza subtype A(H5N1), clade 2.3.2.1c from Cameroon is closely related phylogenetically and antigenically to strains isolated in central and western Africa at the time. No molecular markers of increased human transmissibility were noted; however, seroconversion was detected in two poultry workers (1.5% of total screened). Therefore, the continued outbreaks of avian influenza in poultry and the risk of zoonotic human infection highlight the crucial need for continued and vigilant influenza surveillance and research in Africa, especially in areas of high poultry trade, such as Cameroon.

Item ID: 57044
Item Type: Article (Research - C1)
ISSN: 2222-1751
Keywords: avian influenza, H5N1, Africa, Cameroon, Zoonoses, surveillance, outbreak
Copyright Information: Copyright © 2019 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Funders: US Department of Health and Human Services (US DHHS)
Projects and Grants: US DHHS grant number IDSEP 140020-04-00
Date Deposited: 06 Feb 2019 07:54
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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