Current pharmacotherapy options for conduct disorders in adolescents and children

Khan, Sohil, Down, John, Aouira, Nisreen, Bor, William, Haywood, Alison, Littlewood, Robyn, Heussler, Helen, and McDermott, Brett (2019) Current pharmacotherapy options for conduct disorders in adolescents and children. Expert Opinion of Pharmacotherapy. (In Press)

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Abstract

Introduction: Conduct disorder (CD) is a common mental health disorder of childhood and adolescence. CD’s complexity, with its heterogenous clinical manifestations and overlapping comorbidities makes the application of evidence-based management approaches challenging. This article aims to combine a systematic review of the available literature, with a consensus opinion from both child and adolescent psychiatrists and developmental pediatricians on the clinical and pharmacological management of children and adolescents with conduct disorder (CD).

Areas covered: The authors review the CD population and provide a systematic review and meta-analysis of the effectiveness and safety of pharmacotherapies using preferred reporting items for systematic review and meta-analysis (PRISMA) and strength of evidence recommendation taxonomy (SORT) guidelines. The authors then provide an expert clinical opinion for the use of different pharmacotherapies to address aggressive and disruptive behavior in children.

Expert opinion: Atypical antipsychotics (e.g. risperidone) demonstrate evidence for efficacy in CD. Other pharmacotherapies (e.g. mood stabilizers, anticonvulsants, psychostimulants and selective norepinephrine reuptake inhibitors) have a low level of evidence for CD alone, however, can sometimes be effective in managing the symptoms of CD when other psychiatric disorders are also present.

Item ID: 57014
Item Type: Article (Research - C1)
ISSN: 1744-7666
Keywords: atypical antipsychotics, conduct disorders, risperidone, pharmacotherapy, children, adolescents
Date Deposited: 06 Feb 2019 03:49
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 70%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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