Vanderven, Hillary A., Jegaskanda, Sinthujan, Wheatley, Adam K., and Kent, Stephen J. (2017) Antibody-dependent cellular cytotoxicity and influenza virus. Current Opinion in Virology, 22. pp. 89-96.

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Abstract

Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza specific ADCC antibodies.

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