Antibody-dependent cellular cytotoxicity and influenza virus
Vanderven, Hillary A., Jegaskanda, Sinthujan, Wheatley, Adam K., and Kent, Stephen J. (2017) Antibody-dependent cellular cytotoxicity and influenza virus. Current Opinion in Virology, 22. pp. 89-96.
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Abstract
Antibodies are a key defence against influenza infection and disease, but neutralizing antibodies are often strain-specific and of limited utility against divergent or pandemic viruses. There is now considerable evidence that influenza-specific antibodies with Fc-mediated effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can assist in the clearance of influenza infection in vitro and in animal models. Further, ADCC-mediating antibodies that recognize a broad array of influenza strains are common in humans, likely as a result of being regularly exposed to influenza infections. The concept that influenza-specific ADCC can assist in the partial control of influenza infections in humans is gaining momentum. This review examines the utility of influenza specific ADCC antibodies.
Item ID: | 56891 |
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Item Type: | Article (Research - C1) |
ISSN: | 1879-6265 |
Copyright Information: | © 2016 Elsevier B.V. All rights reserved. |
Funders: | National Health and Medical Research Council (NHMRC) |
Projects and Grants: | NHMRC 1052979 |
Date Deposited: | 16 Jan 2019 07:43 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320405 Humoural immunology and immunochemistry @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320404 Cellular immunology @ 50% |
SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100% |
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