Blackwell, Leonard F., Cooke, Delwyn G., and Brown, Simon (2018) Identifying ovulatory cycles and the day of ovulation by the mis-use of pregnanediol glucuronide excretion rate thresholds. European Journal of Contraception and Reproductive Health Care, 23 (5). pp. 390-391.

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Abstract

[Extract] Sir In a recent paper in this journal, Rosetta et al. [1] compared methods of identifying (i) ovulatory cycles and (ii) the day of ovulation based on intermittent urinary hormone metabolite measurements using expert assessment of the data as a 'gold' standard. Some of their work is based on our pregnanediol-3-glucuronide (PdG) excretion rate threshold(s) which were developed to (i) identify the end of the fertile window of the cycle and (ii) distinguish between different categories of the menstrual cycle [2]. Several issues arise from their report, but we wish to consider only those concerning (a) the implicit assumption that different measures of PdG are equivalent, (b) the criteria used in the expert assessment and (c) the history of intermittent sampling.

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