Goldenberg, Jonathan, Cipriani, Vittoria, Jackson, Timothy N.W., Arbuckle, Kevin, Debono, Jordan, Dashevsky, Daniel, Panagides, Nadya, Ikonomopoulou, Maria P., Koludarov, Ivan, Li, Bin, Santana, Renan Castro, Nouwens, Amanda, Jones, Alun, Hay, Chris, Dunstan, Nathan, Allen, Luke, Bush, Brian, Miles, John J., Ge, Lilin, Kwok, Hang Fai, and Fry, Bryan G. (2018) Proteomic and functional variation within black snake venoms (Elapidae: Pseudechis). Comparative Biochemistry and Physiology - Part C, 205. pp. 53-61.

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Abstract

Pseudechis (black snakes) is an Australasian elapid snake genus that inhabits much of mainland Australia, with two representatives confined to Papua New Guinea. The present study is the first to analyse the venom of all 9 described Pseudechis species (plus one undescribed species) to investigate the evolution of venom composition and functional activity. Proteomic results demonstrated that the typical Pseudechis venom profile is dominated by phospholipase A₂ toxins. Strong cytotoxicity was the dominant function for most species. P. porphyriacus, the most basal member of the genus, also exhibited the most divergent venom composition, being the only species with appreciable amounts of procoagulant toxins. The relatively high presence of factor Xa recovered in P. porphyriacus venom may be related to a predominantly amphibian diet. Results of this study provide important insights to guide future ecological and toxinological investigations.

Item ID:	56640
Item Type:	Article (Research - C1)
ISSN:	1532-0456
Keywords:	venom evolution, Pseudechis, black snakes, diet, toxins, proteomic, enzymology, oxyuraninae, PLA2
Copyright Information:	© 2018 Elsevier Inc. All rights reserved.
Funders:	Science and Technology Development Fund of Macau SAR (FDCT), University of Macau (UM), National Health and Medical Research Council (NHMRC)
Projects and Grants:	FDCT 019/2017/A1, UM Multi-Year Research Grant MYRG2015-00025-FHS, NHMRC Research Fellowship 1131732
Date Deposited:	11 Feb 2019 05:27
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320499 Immunology not elsewhere classified @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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