Mining venoms and their components for drug discovery

Jimenez, Rocio, Ikonomopoulou, Maria P., Lopez, J. Alejandro, and Miles, John J. (2017) Mining venoms and their components for drug discovery. Toxicon, 141. pp. 18-24.

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Abstract

This review catalogues recent advances in knowledge on venoms as standalone therapeutic agents or as blueprints for drug design, with an emphasis on venom-derived compounds that affects the immune system. We discuss venoms and venom-derived compounds that affect total immune cell numbers, immune cell proliferation, immune cell migration, immune cell phenotype and cytokine secretion. Identifying novel compounds that 'tune' the system, up-regulating the immune response during infectious disease and cancer and down-regulating the immune response during autoimmunity, will greatly expand the tool kit of human immunotherapeutics. Targeting these pathways may also open therapeutic options that alleviate symptoms of envenomation. Finally, combining recent advances in venomics with progress in low cost, high-throughput screening platforms will no doubt yield hundreds of prototype immune modulating compounds in the coming years.

Item ID: 56634
Item Type: Article (Research - C1)
ISSN: 1879-3150
Keywords: venom, toxin, therapeutic, immune modulation, immune system
Funders: Perpetual, National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: Perpetual IMPACT IDIPAP2015/1585, NHMRC 1131732
Date Deposited: 18 Dec 2018 02:14
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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