Dysfunctional γδ T cells: a contributing factor for clinical tolerance to malaria?

Eriksson, Emily M., and Schofield, Louis (2015) Dysfunctional γδ T cells: a contributing factor for clinical tolerance to malaria? Annals of Translational Medicine, 3 (S1). S34.

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Abstract

γδ T cells are a small subset of T cells that can rapidly recognize and respond to antigen in a non-MHC restricted manner. The importance of γδ T cells during malaria infection is established by studies in both mouse models and with human cells, where γδ T cells expand during acute blood stage infections (1,2) and control parasitemia (3). We and others have demonstrated that human γδ T cells are one of the predominant cytokine producers following stimulation with Plasmodium-infected red blood cells in vitro (4-6) and following infection (7,8). γδ T cell cytokine responses are also associated with severe disease (9).

Item ID: 56408
Item Type: Article (Editorial)
ISSN: 2305-5839
Copyright Information: © Annals of Translational Medicine. All rights reserved.
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This article is available Open Access via the publisher's website.

Date Deposited: 28 Nov 2018 09:30
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110707 Innate Immunity @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
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