Dysfunctional γδ T cells: a contributing factor for clinical tolerance to malaria?
Eriksson, Emily M., and Schofield, Louis (2015) Dysfunctional γδ T cells: a contributing factor for clinical tolerance to malaria? Annals of Translational Medicine, 3 (S1). S34.
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Abstract
γδ T cells are a small subset of T cells that can rapidly recognize and respond to antigen in a non-MHC restricted manner. The importance of γδ T cells during malaria infection is established by studies in both mouse models and with human cells, where γδ T cells expand during acute blood stage infections (1,2) and control parasitemia (3). We and others have demonstrated that human γδ T cells are one of the predominant cytokine producers following stimulation with Plasmodium-infected red blood cells in vitro (4-6) and following infection (7,8). γδ T cell cytokine responses are also associated with severe disease (9).
Item ID: | 56408 |
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Item Type: | Article (Editorial) |
ISSN: | 2305-5839 |
Copyright Information: | © Annals of Translational Medicine. All rights reserved. |
Additional Information: | This article is available Open Access via the publisher's website. |
Date Deposited: | 28 Nov 2018 09:30 |
FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110707 Innate Immunity @ 100% |
SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 50% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50% |
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