Helminth-induced regulatory T cells and suppression of allergic responses

Logan, Jayden, Navarro, Severine, Loukas, Alex, and Giacomin, Paul (2018) Helminth-induced regulatory T cells and suppression of allergic responses. Current Opinion in Immunology, 54. pp. 1-6.

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Abstract

Infection with helminths has been associated with lower rates of asthma and other allergic diseases. This has been attributed, in part, to the ability of helminths to induce regulatory T cells that suppress inappropriate immune responses to allergens. Recent compelling evidence suggests that helminths may promote regulatory T cell expansion or effector functions through either direct (secretion of excretory/secretory molecules) or indirect mechanisms (regulation of the microbiome). This review will discuss key findings from human immunoepidemiological observations, studies using animal models of disease, and clinical trials with live worm infections, discussing the therapeutic potential for worms and their secreted products for treating allergic inflammation.

Item ID: 56348
Item Type: Article (Research - C1)
ISSN: 1879-0372
Copyright Information: Crown Copyright © 2018 Published by Elsevier Ltd. All rights reserved.
Funders: National Health and Medical Research Council (NHMRC), Queensland Department of Science, Information Technology and Innovation (QDSITI), Children's Hospital Foundation (CHF), James Cook University (JCU), Australian Institute of Tropical Health and Medicine (AITHM)
Projects and Grants: NHMRC grant 1037304, NHMRC Senior Principal Research Fellowship 1117504, CHF Fellowship 50197, JCU Australian Postgraduate Award
Date Deposited: 28 Nov 2018 08:51
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110899 Medical Microbiology not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 50%
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