Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice

Jones, Nigel C., Hudson, Matthew, Foreman, Joshua, Rind, Gil, Hill, Rachel, Manning, Elizabeth E., and van den Buuse, Maarten (2018) Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice. European Journal of Neuroscience, 48 (8). pp. 2816-2825.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website:


Schizophrenia is a complex psychiatric disorder with a heterogeneous aetiology involving genetic and environmental factors. Deficiencies in both brain-derived neurotrophic factor (BDNF) and NMDA receptor function have been implicated in the disorder and may play causal and synergistic roles. Perturbations in the regulation of electrophysiological signals, including high-frequency (gamma: 30-80 Hz and beta: 20-30 Hz) neuronal oscillations, are also associated with the disorder. This study investigated the influence of BDNF deficiency and NMDA receptor hypofunction on electrophysiological responses to brief acoustic stimuli. Adult BDNF heterozygote (BDNF+/-) and wild-type littermate C57Bl/ 6J mice were surgically implanted with EEG recording electrodes. All mice underwent EEG recording sessions to measure ongoing and auditory-evoked electrophysiological responses following treatment with MK-801 (0.3 mg/kg ip) or vehicle. Western blotting on post-mortem cortical tissue assessed parvalbumin and GAD67 expression -markers of interneurons which are involved in the generation of gamma oscillations. Compared with wild-type controls, BDNF+/-mice exhibited markedly dampened electrophysiological responses to auditory stimuli, including reductions in the amplitude of multiple components of the event-related potential and auditory-evoked oscillations, as well as reduced ongoing cortical gamma oscillations. MK-801 elevated ongoing gamma power but suppressed evoked gamma power, and this was observed equally across genotypes. BDNF+/-mice also displayed reductions in parvalbumin, but not GAD67 expression. We conclude that reduced BDNF expression leads to impairments in the generation of high-frequency neural oscillations, but this is not synergistic with NMDA receptor hypofunction. Reduced parvalbumin expression associated with BDNF haploinsufficiency may provide a molecular explanation for these electrophysiological deficits.

Item ID: 56176
Item Type: Article (Research - C1)
ISSN: 1460-9568
Keywords: brain-derived neurotrophic factor, electrophysiology, event-related potential, gamma oscillations, NMDA receptors, parvalbumin
Copyright Information: © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
Funders: Australian Research Council (ARC), National Health and Medical Research Council of Australia (NHMRC).
Projects and Grants: ARC Future Fellowship FT130100100, NHMRC Grant Number: 1059860, NHMRC Grant Number: 1044777
Date Deposited: 21 Nov 2018 09:30
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page