The role of obesity in inflammatory bowel disease

Kreuter, Roxane, Wankell, Miriam, Ahlenstiel, Golo, and Hebbard, Lionel (2019) The role of obesity in inflammatory bowel disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1865 (1). pp. 63-72.

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In just over a generation overweight and obesity has become a worldwide health concern. The ramifications for this on future health care costs and longevity are consequent, whilst increased adiposity is a harbinger for diabetes, kidney and bone failure, and cancer. An area of intense interest where the role of adiposity is avidly discussed is in inflammatory bowel disease (IBD), which presents mainly as Crohn's disease (CD) and ulcerative colitis (UC). Studies in patients associating IBD with a western diet are divergent. Nevertheless, elegant studies have found gene polymorphisms in humans that in murine models parallel the inflammatory and gut micro- biome changes seen in IBD patients. However, an area not to be ignored are the alterations in adipocyte function with ensuing adiposity, in particular and a focus of this review, the dysregulation of the levels of adipocytokines such as leptin and adiponectin. Herein, we present and discuss the known influences of a western diet on IBD in patients and rodent models and how adipocytokines could influence the IBD disease process.

Item ID: 56146
Item Type: Article (Research - C1)
ISSN: 0925-4439
Keywords: adipocytokines; adiponectin; inflammation; bowel disease
Copyright Information: Copyright © 2018 Elsevier B.V. All rights reserved.
Funders: Cancer Council Queensland (CCQ), James Cook University (JCU)
Projects and Grants: CCQ Grant APP1123436, JCU Development Grant 94066
Date Deposited: 16 Nov 2018 01:07
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320209 Gastroenterology and hepatology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders @ 100%
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