The relationship between CD34+ stem cell dose and time to neutrophil recovery in autologous haematopoietic stem cell recipients: a single centre experience

Nath, Karthik, Boles, Rachael, McCutchan, Andrew, Vangaveti, Venkat, Birchley, Andrew, and Irving, Ian (2018) The relationship between CD34+ stem cell dose and time to neutrophil recovery in autologous haematopoietic stem cell recipients: a single centre experience. Transfusion and Apheresis Science, 57 (4). pp. 532-536.

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Abstract

A retrospective, observational study was performed of 112 patients who underwent autologous haematopoietic stem cell transplantation (ASCT) to determine the relationship between CD34+ stem cell dose and neutrophil engraftment. Importantly, a novel approach to more accurately calculate time to neutrophil engraftment was employed. The results demonstrated that a higher CD34+ stem cell dose was associated with faster neutrophil recovery (P < 0.05). CD34+ stem cell dose using actual and ideal patient body weight were both equally predictive of neutrophil engraftment as were absolute and viable CD34+ measurements. The clinical implications for this relationship are limited with an increase in CD34+ stem cell dose by 1 × 106/kg reducing the neutrophil engraftment time by only 3 h and 50 min. The median time to neutrophil recovery was 217 h (9 days and 1 h) and this relatively early engraftment time may be related to an early initiation of granulocyte colony-stimulating factor (G-CSF) on day +1 post-transplant. Female patients engrafted 17 h faster than their male counterparts on multi-variate analysis (P < 0.05). Conditioning chemotherapy, bacteraemia, G-CSF dose/kg body weight and increasing age had no impact on time to neutrophil recovery.

Item ID: 56058
Item Type: Article (Research - C1)
ISSN: 1878-1683
Keywords: autologous stem cell transplantation; engraftment; CD34+ cell dose; granulocyte colony-stimulating factor
Copyright Information: Crown Copyright © 2018 Published by Elsevier Ltd. All rights reserved.
Date Deposited: 07 Nov 2018 08:12
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy) @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111206 Haematological Tumours @ 20%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110708 Transplantation Immunology @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 80%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 20%
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