Longitudinal changes of day-time and night-time gross motor activity in clinical responders and non-responders of major depression

Todder, Doron, Caliskan, Serdal, and Baune, Bernhard T. (2009) Longitudinal changes of day-time and night-time gross motor activity in clinical responders and non-responders of major depression. World Journal of Biological Psychiatry, 10 (4). pp. 276-284.

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Psychomotor retardation (PR) is among the most important features of depression. This study investigates the development of day- and night-time as well as intensity and quantity of circadian motor activity during a 4-week course of treatment among 27 patients with depression compared to 27 healthy controls. A diagnosis of major depression was made using SCID. Motor activity was continuously measured with an actigraph during the study and clinical course of depression with HAM-D-21. Motor activity was described as the quantity and intensity of movements during day- and night- time. Clinically improved patients had significantly intensified movements after 4 weeks, compared to subjects with <50% improvement on HAM-D. While the measures of day-time level of movements captured the clinical improvement of depression, clinical improvement was not reflected by the night-time measurements. This study demonstrates that the separated analysis of level and quantity of movements supports a better understanding of the nature of psychomotor retardation during depression. The subdivision in day- and night-time activity objectively measured with actigraphy captures distinct patterns of motor activity and represents prognostic factors in the treatment outcome of depression. The study also highlights the importance of studying the intensity of movements separately from the quantity of movements in relation to treatment outcome.

Item ID: 5595
Item Type: Article (Research - C1)
ISSN: 1814-1412
Keywords: day and night-time locomotor activity, depression, actigraphy intensity and quantity of movements, psychopathology
Date Deposited: 01 Dec 2009 22:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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