The role of kidney DNA methylation in hypertensive gene expression

Wise, Ingrid (2017) The role of kidney DNA methylation in hypertensive gene expression. In: [Presented at the Annnual Research Conference of the Federation University Australia]. From: Federation University Australia's Annual Research Conference, 2017, Ballarat, VIC, Australia.

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Background and aims: Epigenetic modifications are recognised as essential processes in biology, but are now being investigated for their role in the development of pathologic conditions, including essential hypertension. To date, there has been no studies of DNA methylation patterns in the kidney – an important effector organ in blood pressure regulation. The aim of this study was to compare loci specific (CpG site) methylation in the kidney between hypertensive and normotensive subjects, offering mechanistic insights into the genetic physiology of hypertension.

Methods and results: Ninety-six human renal samples from the TRANSLATE study were used for both the DNA methylation analysis. TRANSLATE consists of carefully characterised collections of “apparently healthy” specimens of human kidneys.

Twenty-nine CpG sites were differentially methylated between the two population groups (P=<.0001), corresponding to 19 protein coding genes. Further, 17 CpG sites were differentially methylated (P=<.0001) when the analysis was adjusted for common covariates (smoking status, diabetes, age and gender), corresponding to 12 protein coding gene sites. Among these loci were genes previously associated to cell survival/ apoptotic pathways, calcium binding and protein folding.

Conclusions: DNA methylation in the kidney may be an important molecular mechanism for the expression of genes responsible for the modulation of blood pressure and hypertension in humans.

Item ID: 55720
Item Type: Conference Item (Abstract / Summary)
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Date Deposited: 23 Oct 2018 23:50
FoR Codes: 06 BIOLOGICAL SCIENCES > 0604 Genetics > 060404 Epigenetics (incl Genome Methylation and Epigenomics) @ 50%
06 BIOLOGICAL SCIENCES > 0604 Genetics > 060408 Genomics @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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