A diet enriched with tree nuts reduces severity of atherosclerosis but not abdominal aneurysm in angiotensin II-infused apolipoprotein E deficient mice

Phie, James, Moxon, Joseph V., Krishna, Smriti M., Kinobe, Robert, Morton, Susan K., and Golledge, Jonathan (2018) A diet enriched with tree nuts reduces severity of atherosclerosis but not abdominal aneurysm in angiotensin II-infused apolipoprotein E deficient mice. Atherosclerosis, 277. pp. 28-33.

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Abstract

Background and aims: Diets enriched with tree nuts have been demonstrated to reduce the risk of atherosclerosis-related cardiovascular events. Abdominal aortic aneurysm (AAA) shares common risk factors with atherosclerosis and AAA patients commonly have atherosclerosis related cardiovascular events. AAA has some distinct pathological and clinical characteristics to those of atherosclerosis. No previous study has examined the effect of a diet enriched with tree nuts on experimental or clinical AAA. This study investigated the effect of a diet enriched with tree nuts on the development and severity of AAA within an experimental rodent model.

Methods: Male apolipoprotein E deficient mice were allocated to a diet enriched with tree nuts or control diet for 56 days (n = 17 per group). After 28 days, all mice were infused with angiotensin II whilst being maintained on their respective diets. The primary outcome was AAA severity assessed by the supra-renal aortic diameter, measured by ultrasound and ex vivo morphometric analysis. The severity of atherosclerosis was assessed by computer-aided analysis of Sudan IV stained aortic arches and sections of brachiocephalic arteries prepared with Van Gieson's stain.

Results: The diet enriched with tree nuts did not influence aortic diameter or aortic rupture incidence. Mice receiving the diet enriched with tree nuts had significantly less atherosclerosis within the brachiocephalic artery (p = 0.033) but not in the aortic arch.

Conclusions: This experimental study suggests that a diet enriched with tree nuts does not reduce the severity of AAA, but does reduce the severity of atherosclerosis within the brachiocephalic artery. The study was not powered to identify a moderate effect of the diet on the primary outcome and therefore this cannot be excluded.

Item ID: 55677
Item Type: Article (Research - C1)
ISSN: 1879-1484
Keywords: diet; atherosclerosis; aneurysm; angiotensin II; polyphenol; polyunsaturated; fatty acid
Copyright Information: Copyright © 2018 Elsevier B.V. All rights reserved.
Additional Information:

Supplementary data related to this article can be found at https://doi.org/10.1016/j.atherosclerosis.2018.08.004

Funders: National Health and Medical Research Council (NHMRC), Queensland Government (QG), James Cook University (JCU)
Projects and Grants: NHMRC Grant No. 1098717, NHMRC Grant No. 1117061, QG Advance Queensland Fellowship, QG Senior Clinical Fellowship
Date Deposited: 09 Oct 2018 02:34
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition @ 100%
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