Factors associated with the risk of developing coronary artery disease in medicated patients with major depressive disorder

Ho, Roger C.M., Chua, Anna C., Tran, Bach X., Choo, Carol C., Husain, Syeda Fabeha, Vu, Giang T., Mcintyre, Roger S., and Ho, Cyrus S.H. (2018) Factors associated with the risk of developing coronary artery disease in medicated patients with major depressive disorder. International Journal of Environmental Research and Public Health, 15 (10). pp. 2073-2086.

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Background: The aim of this study was to identify factors associated with high Framingham Risk Score (FRS) in medicated patients with major depressive disorder (MDD).

Methods: We examined 61 medicated patients with MDD (mean age 37.77 ± 7.67, 90.2% women) and 43 non-depressed controls (mean age 38.26 ± 9.20, 90.7% women). We administered the Hamilton Depression Rating Scale (HAM-D) and measured systolic blood pressure (SBP), diastolic BP (DBP), mean arterial BP (MAP), pulse wave velocity (PWV), intima-media thickness (IMT), interleukin-6 (IL-6) and triglycerides.

Results: We found that medicated patients with MDD had significantly higher levels of HAM-D score (p < 0.01), SBP (p = 0.015), MAP (p = 0.037), IL−6 level (p = 0.007), as compared with controls. Medicated patients who remained moderately to severely depressed showed significantly higher SBP (p = 0.049), DBP (p = 0.009), MAP (p = 0.024), IL−6 level (p = 0.019), left PWV (p = 0.004) and average PWV (p = 0.026) than those with mild depression. Multivariate regression showed that the interaction effect between HAM-D score and triglyceride level (p = 0.018) was significantly associated with FRS in medicated patients with MDD.

Conclusions: This study highlights that the interaction effect of the severity of depression and the triglyceride level, was a modifiable factor positively associated with high FRS.

Item ID: 55674
Item Type: Article (Research - C1)
ISSN: 1660-4601
Keywords: antidepressants; cytokines; depression; Framingham risk score; Hamilton depression rating scale; pulse wave velocity; triglycerides
Copyright Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Funders: National University of Singapore (NUS)
Projects and Grants: NUS Grant R-177-000-027-133, NUS Grant R-177-000-033-733
Date Deposited: 24 Oct 2018 01:10
FoR Codes: 52 PSYCHOLOGY > 5203 Clinical and health psychology > 520304 Health psychology @ 100%
SEO Codes: 92 HEALTH > 9202 Health and Support Services > 920299 Health and Support Services not elsewhere classified @ 100%
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