Antimicrobial sensitivity trends and virulence genes in Shigella spp. from the Oceania region

Malau, Elisheba, Ford, Rebecca, Valcanis, Mary, Jennison, Amy V., Mosse, Jenny, Bean, David, Yoannes, Mition, Pomat, William, Horwood, Paul F., and Greenhill, Andrew R. (2018) Antimicrobial sensitivity trends and virulence genes in Shigella spp. from the Oceania region. Infection, Genetics and Evolution, 64. pp. 52-56.

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Abstract

Shigella is a common cause of diarrhoea in Papua New Guinea (PNG) and other Oceania countries. However, little is known about the strains causing infection. Archived Shigella isolates (n = 72) were obtained from research laboratories in PNG and reference laboratories in Australia. Shigella virulence genes were detected by PCR, and antimicrobial susceptibility was determined by disk diffusion. The ipaH virulence gene was present in all 72 isolates. The prevalence of other virulence genes was variable, with ial, invE, ipaBCD, sen/ospD3 and virF present in 60% of isolates and set1A and set1B genes present in 42% of isolates. Most S. flexneri isolates contained genes encoding enterotoxin 1 and/or enterotoxin 2. Resistance to antibiotics was common, with 51/72 isolates resistant to 2-4 antimicrobials. A greater proportion of bacteria isolated since 2010 (relative to pre-2010 isolates) were resistant to commonly used antibiotics such as ampicillin, chloramphenicol, tetracycline, and trimethoprim-sulfamethoxazole; suggesting that antimicrobial resistance (AMR) in Shigella is increasing over time in the Oceania region. There is a need for improved knowledge regarding Shigella circulation in the Oceania region and further monitoring of AMR patterns.

Item ID: 55627
Item Type: Article (Research - C1)
ISSN: 1567-7257
Keywords: shigellosis, shigella, antimicrobial resistance, virulence genes, surveillance, oceania, Papua New Guinea
Copyright Information: Copyright © 2018 Elsevier B.V. All rights reserved
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Peer review: This journal operates a single blind review process. All contributions will be initially assessed by the editor for suitability for the journal. Papers deemed suitable are then typically sent to a minimum of two independent expert reviewers to assess the scientific quality of the paper. The Editor is responsible for the final decision regarding acceptance or rejection of articles. The Editor's decision is final. More information on types of peer review.

Funders: Federation University Australia
Date Deposited: 19 Sep 2018 09:48
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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