Immunobiology of parasitic worm extracellular vesicles

Eichenberger, Ramon M., Sotillo, Javier, and Loukas, Alex (2018) Immunobiology of parasitic worm extracellular vesicles. Immunology and Cell Biology, 96 (7). pp. 704-713.

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Abstract

Helminth parasites (worms) have evolved a vast array of strategies to manipulate their vertebrate hosts. Extracellular vesicles (EVs) are secreted by all helminth species investigated thus far, and their salient roles in parasite-host interactions are being revealed. Parasite EVs directly interact with various cell types from their hosts, including immune cells, and roles for their molecular cargo in both regulation and promotion of inflammation in the host have been reported. Despite the growing body of literature on helminth EVs, limited availability of genetic manipulation tools for helminth research has precluded detailed investigation of specific molecular interactions between parasite EVs and host target cells. Here, we review the current state of the field and discuss innovative strategies targeting helminth EVs for the discovery and development of new therapeutic strategies, placing particular emphasis on both anti-helminth vaccines and EV small RNAs for treating noninfectious inflammatory diseases.

Item ID: 55308
Item Type: Article (Research - C1)
ISSN: 1440-1711
Keywords: exosome, extracellular vesicle, helminth, immunology, parasite-host interaction, worm
Date Deposited: 05 Sep 2018 09:34
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110899 Medical Microbiology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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