Correlation between serum cryptococcal antigen titre and meningitis in immunocompetent patients

Gassiep, Ian, Chaw, Aye, Armstrong, Mark, Emeto, Theophilus I., Heather, Christopher S., and Norton, Robert E. (2018) Correlation between serum cryptococcal antigen titre and meningitis in immunocompetent patients. Journal of Medical Microbiology, 67 (10). pp. 1515-1518.

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The aim of this paper was to determine the correlation between serum cryptococcal antigen and a diagnosis of cryptococcal meningitis in the immunocompetent cohort. A retrospective multicentre analysis of immunocompetent patients diagnosed and treated for cryptococcal meningitis between January 2000 and December 2017 was performed. Sixty-seven of the 143 cases of cryptococcosis occurred in immunocompetent patients. The serum cryptococcal antigen titre was significantly higher in the meningitis group [1 : 256 (IQR: 64–1024)] compared with that for non-meningitis patients [1 : 64 (IQR: 8–256)], P=0.012. The relative risk of meningitis with a serum cryptococcal antigen (CRAG) >1 : 64 was 1.8 (95 % CI: 1.15–2.82). This study demonstrates a clear correlation between serum cryptococcal antigen titre and meningitis. While the serum titre is not definitive for meningitis, in resource-limited settings or cases where lumbar puncture may be contraindicated, this evidence may aid diagnosis and subsequent therapeutic decisions.

Item ID: 55217
Item Type: Article (Research - C1)
ISSN: 1473-5644
Keywords: cryptococcosis, cryptococcal meningitis, immunocompetent, cryptococcal antigen
Copyright Information: © 2018 The Authors
Date Deposited: 24 Aug 2018 01:14
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 80%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 20%
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