Malau-Aduli, A.E.O., Bignell, C.W., McCulloch, R., Nichols, P.D., and Kijas, J.W. (2011) Genetic association of delta-six fatty acid desaturase single nucleotide polymorphic molecular marker and muscle long chain omega-3 fatty acids in Australian lamb. In: Proceedings of the 57th International Congress of Meat Science and Technology (1) pp. 141-144. From: ICoMST 2011: 57th International Congress of Meat Science and Technology, 7-12 August 2011, Ghent, Belgium.

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Abstract

For sustainable prime lamb production in the Australian sheep industry and a better understanding of the relationships between fat metabolism-related genes and sheep muscle long chain omega-3 polyunsaturated fatty acids, we investigated the genetic association between polyunsaturated fatty acids (PUFAs), delta-6 desaturase (FADS2) and fatty acid binding protein(FABP) gene clusters in crossbred sheep. Thirty-one single nucleotide polymorphisms (SNPs) were genotyped in Longissimus dorsi muscle samples from 362 crossbred prime lambs sired by five genetically divergent rams. Total intramuscular lipid long chain fatty acid levels were analysed using gas chromatography. Genetic association was tested for significance using mixed model analyses in SAS fitting genotype, sire breed and sex as fixed effects and sire as a random variable. FAPB SNP was highly significantly associated (P<0.05) with 18:4n-3 (stearidonic acid), while FADS2 SNP was significantly associated (P<0.05) with intramuscular levels of eicosapentaenoic (C20:5n-3) and docosahexaenoic (C22:6n-3) acids. The results suggest that this SNP is in linkage disequilibrium with functional lipid synthesis pathway associated with higher delta-six desaturase activity. For the first time, this study provides evidence for an association between genetic variants of FADS2 and omega-3 PUFA in sheep muscle. This SNP could potentially be a novel marker of choice for prime lamb producers to effectively select for enhanced muscle omega-3 fatty acid content in their breeding flock.

Item ID:	55050
Item Type:	Conference Item (Research - E1)
ISBN:	978-1-62276-056-5
Related URLs:	http://www.proceedings.com/15027.html
Date Deposited:	29 Aug 2018 03:19
FoR Codes:	07 AGRICULTURAL AND VETERINARY SCIENCES > 0702 Animal Production > 070201 Animal Breeding @ 100%
SEO Codes:	83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8303 Livestock Raising > 830310 Sheep - Meat @ 100%
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