Antonsson, Annika, Waterboer, Tim, Bouwes Bavinck, Jan N., Abeni, Damiano, de Koning, Maurits, Euvrard, Sylvie, Feltkamp, Mariet C. W., Green, Adèle C., Harwood, Catherine A., Naldi, Luigi, Nindl, Ingo, Pfister, Herbert J., Proby, Charlotte M., Quint, Wim G., Stockfleth, Eggert, Weissenborn, Sönke J., Pawlita, Michael, Neale, Rachel E., and The EPI-HPV-UV-CA group, (2013) Longitudinal study of seroprevalence and serostability of 34 human papillomavirus types in European organ transplant recipients. Virology, 436 (1). pp. 91-99.

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Abstract

Organ transplant recipients (OTR) are at increased risk of cutaneous squamous cell carcinoma, which may be related to reactivation of human papillomavirus (HPV) infections. Measurement of change in HPV antibodies after transplantation would help to explore this hypothesis.

We measured antibodies to 34 HPV types on up to six occasions over 18 months in 441 OTRs from five European countries.

At baseline (mean 24 days after transplantation), 80% of all OTRs were seropositive to at least one HPV type. The beta HPV genus had the highest seroprevalence (45%). For most HPV genera baseline seroprevalence peaked between 40 and 59 years old. Most OTRs retained their serostatus over time and antibody levels were stable.

Seroprevalence in immunosuppressed OTRs is stable in the 18 months immediately after transplantation. Thus there is no short-term evidence that immunosuppression leads to new or reactivated skin infection with HPV sufficient to induce antibodies.

Item ID:	55001
Item Type:	Article (Research - C1)
ISSN:	1089-862X
Keywords:	human papillomavirus; serology; organ transplant; longitudinal study; seroprevalence; antibody stability; skin
Copyright Information:	Copyright © 2012 Elsevier Inc. All rights reserved.
Additional Information:	Dr Simone Harrison is a member of the The EPI-HPV-UV-CA group of researchers.
Funders:	European Commission (EC), Cancer Council Queensland (CCQ)
Projects and Grants:	EC QLK2-CT-2002-01179
Date Deposited:	09 Dec 2019 02:34
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 100%
SEO Codes:	92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 80% 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 20%
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