Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: a multicenter, prospective cohort study

Bouwes Bavinck, Jan N., Feltkamp, Mariet C.W., Green, Adele C., Fiocco, Marta, Euvrard, Sylvie, Harwood, Catherine A., Nasir, Shaaira, Thomson, Jason, Proby, Charlotte M., Naldi, Luigi, Diphoorn, Janouk C.D., Venturuzzo, Anna, Tessari, Gianpaolo, Nindl, Ingo, Sampogna, Francesca, Abeni, Damiano, Neale, Rachel E., Goeman, Jelle J., Quint, Koen D., Halk, Anne B., Sneek, Carmen, Genders, Roel E., de Koning, Maurits, Quint, Wim G.V., Wieland, Ulrike, Weissenborn, Sönke, Waterboer, Tim, Pawlita, Michael, Pfister, Herbert, and EPI-HPV-UV-CA group, (2018) Human papillomavirus and posttransplantation cutaneous squamous cell carcinoma: a multicenter, prospective cohort study. American Journal of Transplantation, 18 (5). pp. 1220-1230.

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Abstract

Organ transplant recipients (OTRs) have a 100- fold increased risk of cutaneous squamous cell carcinoma (cSCC). We prospectively evaluated the association between β genus human papillomaviruses (βPV) and keratinocyte carcinoma in OTRs. Two OTR cohorts without cSCC were assembled: cohort 1 was transplanted in 2003-2006 (n = 274) and cohort 2 was transplanted in 1986-2002 (n = 352). Participants were followed until death or cessation of follow-up in 2016. βPV infection was assessed in eyebrow hair by using polymerase chain reaction–based methods. βPV IgG seroresponses were determined with multiplex serology. A competing risk model with delayed entry was used to estimate cumulative incidence of histologically proven cSCC and the effect of βPV by using a multivariable Cox regression model. Results are reported as adjusted hazard ratios (HRs). OTRs with 5 or more different βPV types in eyebrow hair had 1.7 times the risk of cSCC vs OTRs with 0 to 4 different types (HR 1.7, 95% confidence interval 1.1- 2.6). A similar risk was seen with high βPV loads (HR 1.8, 95% confidence interval 1.2- 2.8). No significant associations were seen between serum antibodies and cSCC or between βPV and basal cell carcinoma. The diversity and load of βPV types in eyebrow hair are associated with cSCC risk in OTRs, providing evidence that βPV is associated with cSCC carcinogenesis and may present a target for future preventive strategies.

Item ID: 54999
Item Type: Article (Refereed Research - C1)
Keywords: cancer; malignancy; neoplasia; risk factors; skin neoplasia; nonmelanoma; clinical research; clinical practice; infection and infectious agents; viral; papillomavirus; organ transplantation in general
Copyright Information: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2017 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Funders: European Union 5th Framework Programme (EU5FP), Italian Ministry of Health (IMH)
Projects and Grants: EU5FP QLK2- CT- 2002- 0117, IMH Progetto Ricerca Corrente
Date Deposited: 14 Aug 2018 00:16
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 25%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine @ 25%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 50%
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