WHO/IUIS Allergen Nomenclature: Providing a common language

Pomés, Anna, Davies, Janet M., Gadermaier, Gabriele, Hilger, Christiane, Holzhauser, Thomas, Lidholm, Jonas, Lopata, Andreas L., Mueller, Geoffrey A., Nandy, Andreas, Radauer, Christian, Chan, Sanny K., Jappe, Uta, Kleine-Tebbe, Jörg, Thomas, Wayne R., Chapman, Martin D., van Hage, Marianne, van Ree, Ronald, Vieths, Stefan, Raulf, Monika, and Goodman, Richard E. (2018) WHO/IUIS Allergen Nomenclature: Providing a common language. Molecular Immunology, 100. pp. 3-13.

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A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a text table online, then converted to a more readily updated website. The allergen list became the Allergen Nomenclature database (www.allergen.org ), which currently includes approximately 880 proteins from a wide variety of sources. The Sub-Committee includes experts on clinical and molecular allergology. They review submissions of allergen candidates, using evidence-based criteria developed by the Sub-Committee. The review process assesses the biochemical analysis and the proof of allergenicity submitted, and aims to assign allergen names prior to publication. The Sub-Committee maintains and revises the database, and addresses continuous challenges as new "omics" technologies provide increasing data about potential new allergens. Most journals publishing information on new allergens require an official allergen name, which involves submission of confidential data to the WHO/IUIS Allergen Nomenclature Sub-Committee, sufficient to demonstrate binding of IgE from allergic subjects to the purified protein.

Item ID: 54932
Item Type: Article (Research - C1)
ISSN: 1872-9142
Keywords: Allergen database, WHO/LUIS Allergen Nomenclature, IgE, Taxonomic name, Isoallergen
Copyright Information: © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC Project Grant 1086656
Date Deposited: 08 Aug 2018 07:36
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 70%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320506 Medical biochemistry - proteins and peptides (incl. medical proteomics) @ 30%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 80%
92 HEALTH > 9202 Health and Support Services > 920203 Diagnostic Methods @ 20%
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