The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

Luo, Jie Denny, Miller, Catherine, Jirjis, Tamara, Nasir, Masoud, and Sharma, Dileep (2018) The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review. International Journal of Implant Dentistry, 4. 30.

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Abstract

Non-steroidal anti-inflammatory drugs are commonly used in implant dentistry for management of post-operative pain. The objective of this systematic review was to analyse the effect of non-steroidal anti-inflammatory drugs on the osteogenic activity of osteoblasts with an emphasis on its effect on osseointegration. A systematic literature search for in-vitro, animal models, and clinical trials was conducted using Ovid, PubMed, Scopus and Web of Science databases. Articles published since the introduction of selective COX-2 inhibitors, between January 1999 and May 2018, were selected. The integrated search followed the PRISMA statement with the following key terms; non-steroidal anti-inflammatory drug/s, titanium, osseointegration, osteoblast. The review is registered at PROSPERO database: CRD42016051448. The titles and abstracts of each research article in the initial search (n=875) were independently screened by two reviewers. A third independent reviewer reviewed the articles that were included by one but excluded by the other reviewer. This resulted in the cataloguing of 79 full-text manuscripts where the articles were assessed for the following criteria: the study investigates the effects of NSAIDs on osteoblasts, explored the COX pathway and its effect on osteogenic activity, and compares the effects of NSAIDs on osteoblasts with a control group. A total of 13 articles have been included for qualitative synthesis. There is a lack of consensus in the literature to explicitly conclude that there is a relationship between the use of post-operative NSAIDs and failed osseointegration, however, osseointegration does not appear to be negatively affected by NSAIDs in the human clinical studies.

Item ID: 54666
Item Type: Article (Research - C1)
ISSN: 2198-4043
Keywords: non-steroidal anti-inflammatory drug; osseointegration; osteoblast; dental implant
Copyright Information: © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made.
Funders: James Cook University (JCU)
Projects and Grants: JCU Dentistry Honours Research Project
Date Deposited: 19 Jul 2018 04:41
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110502 Dental Therapeutics, Pharmacology and Toxicology @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920402 Dental Health @ 50%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 50%
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