A randomised controlled trial of consumption of dark chocolate in pregnancy to reduce pre-eclampsia: difficulties in recruitment, allocation and adherence

Gnanendran, Subashini, Porrett, Jemma, Woods, Cindy, Buttrose, Maryke, Jukka, Clare, Hollins, Jane, Robson, Stephen, and de Costa, Caroline (2018) A randomised controlled trial of consumption of dark chocolate in pregnancy to reduce pre-eclampsia: difficulties in recruitment, allocation and adherence. Australian and New Zealand Journal of Obstetrics and Gynaecology, 58 (3). pp. 358-361.

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Abstract

In 2013-2014 we undertook a randomised controlled trial (RCT) to determine whether the daily ingestion of dark chocolate during pregnancy could reduce the incidence of pre-eclampsia in primigravidae. However, after two years we had not succeeded in recruiting more than 3.5% of the number of participants required to answer the research question, and the trial was halted. We also reviewed the literature on this topic and found it to be limited. We report here our findings and discuss the difficulties facing researchers in this area.

Item ID: 54344
Item Type: Article (Research - C1)
ISSN: 1479-828X
Keywords: dark chocolate, dark chocolate in pregnancy, flavonoid rich dark chocolate, pre-eclampsia
Copyright Information: Copyright © 2017 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Date Deposited: 27 Jun 2018 07:34
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111402 Obstetrics and Gynaecology @ 100%
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