The correlation between diverticulosis and redundant colon
Cuda, Tahleesa, Gunnarsson, Ronny, and De Costa, Alan (2017) The correlation between diverticulosis and redundant colon. ANZ Journal of Surgery, 87 (S1). p. 30.
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Abstract
Purpose: Diverticulosis and redundant colon are colonic conditions for which underlying pathophysiology, management and prevention are poorly understood. Historical papers suggest an inverse relationship of these two conditions. However, no further attempt has been made to validate this relationship. This study set out to assess the correlation between diverticulosis and colonic redundancy.
Methodology: The presence of redundant colon and diverticulosis were noted during colonoscopy. Multivariate binary logistic regression was per-formed with the aim of developing a probability nomogram. Multivariate logistic regression was performed with redundant colon as the dependent variable and diverticulosis, age and gender as independent variables. Nagelkerke R2 and a receiver operator curve with area under curve were calculated to assess goodness off it and internally validate the multivariate model.
Results: The probability of redundant colon was increased by female gender odds ratio (OR) 8.4 (95% CI 2.7-26, p=0.00020) and increasing age OR 1.7 (95% CI 1.1-2.6, p=0.017). Paradoxically, diverticulosis strongly reduced the probability of redundant colon with OR of 0.12 (95% CI 0.42-0.32, p=0.000039). The Nagelkerke R2 for the multivariate model was 0.29and area under the curve at ROC analysis was 0.81 (CI 95% 0.73-0.90 p-value 3.1x10-8).
Conclusions: This study found an inverse correlation between redundant colon and diverticulosis, supporting the historical suggestion that the two conditions rarely occur concurrently. The underlying principle for this relationship remains to be found. However, it may contribute to the understanding of the aetiology and pathophysiology of these colonic conditions
| Item ID: | 54134 |
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| Item Type: | Article (Abstract) |
| ISSN: | 1445-2197 |
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| Additional Information: | Presented at: Cuda, Tahleesa, Gunnarsson, Ronny, and De Costa, Alan (2017) The correlation between diverticulosis and redundant colon. In: ANZ Journal of Surgery (87), p. 30. From: Royal Australian College of Surgeons 2017 Annual Scientific Congress, 8-12 May 2017, Adelaide, SA, Australia. This work has also been published as Cuda, Tahleesa, Gunnarsson, Ronny, and De Costa, Alan (2017) The correlation between diverticulosis and redundant colon. International Journal of Colorectal Disease, 32 (11). pp. 1603-1607 and is available through ResearchOnline at the related URL. |
| Date Deposited: | 18 Jun 2018 05:47 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110323 Surgery @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures @ 100% |
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