Anti-troponin antibodies following myocardial infarction

O'Donohoe, Tom J., Ketheesan, Natkunam, and Schrale, Ryan G. (2017) Anti-troponin antibodies following myocardial infarction. Journal of Cardiology, 69 (1). pp. 38-45.

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Abstract

Recent improvements in medical and surgical coronary revascularization techniques have significantly improved outcomes for patients with acute myocardial infarction (MI). However, large infarctions are often followed by a poorly understood process of pathological ventricular remodelling, which fails to return the heart to its premorbid state. Although it remains incompletely understood, there is increasing interest in the role of the immune system in this process. One hypothesis is that released cardiac proteins become the focus of an immune response that results in the formation of functionally significant autoantibodies. This review summarizes the current literature, both human and animal, relating to the formation and clinical relevance of anti-troponin antibodies (ATAs) in patients with MI.

Item ID: 54077
Item Type: Article (Research - C1)
ISSN: 1876-4738
Keywords: anti-troponin antibodies; autoantibody; autoimmunity; ischaemic heart disease; myocardial infarction
Funders: Townsville Hospital and Health Service (THHS)
Projects and Grants: THHS RG/2015/13
Date Deposited: 14 Jun 2018 23:37
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 60%
11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 60%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 40%
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