Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease
Deenonpoe, Raksawan, Mairiang, Eimorn, Mairiang, Pisaln, Pairojkul, Chawalit, Chamgramol, Yaovalux, Rinaldi, Gabriel, Loukas, Alex, Brindley, Paul J., and Sripa, Banchob (2017) Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease. Scientific Reports, 7. 42744.
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Abstract
Recent reports suggest that Opisthorchis viverrini serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasis-associated cholangiocarcinoma (CCA). Here, 553 age-sex matched cases and controls, 293 and 260 positive and negative for liver fluke O. viverrini eggs, of residents in Northeastern Thailand were investigated for associations among infection with liver fluke, Helicobacter and hepatobiliary fibrosis. The prevalence of H. pylori infection was higher in O. viverrini-infected than uninfected participants. H. pylori bacterial load correlated positively with intensity of O. viverrini infection, and participants with opisthorchiasis exhibited higher frequency of virulent cagA-positive H. pylori than those free of fluke infection. Genotyping of cagA from feces of both infected and uninfected participants revealed that the AB genotype accounted for 78% and Western type 22%. Participants infected with O. viverrini exhibited higher prevalence of typical Western type (EPIYA ABC) and variant AB'C type (EPIYT B) CagA. Multivariate analyses among H. pylori virulence genes and severity of hepatobiliary disease revealed positive correlations between biliary periductal fibrosis during opisthorchiasis and CagA and CagA with CagA multimerization (CM) sequence-positive H. pylori. These findings support the hypothesis that H. pylori contributes to the pathogenesis of chronic opisthorchiasis and specifically to opisthorchiasis-associated CCA.
| Item ID: | 53981 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 2045-2322 |
| Additional Information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Funders: | Commission on Higher Education, Thailand (CHE), Thailand Research Fund (TRF), National Health and Medical Research Council (NHMRC), National Health Security Office, Thailand, Higher Education Research Promotion and National University Project of Thailand, Khon Kaen University (KKU), National Research Council, Thailand (NRC), National Institute of Allergy and Infectious Diseases (NIAID), Tropical Medicine Research Centre (TMRC), National Cancer Institute (NCI), United States Army Medical Research and Material Command (USAMRMC) |
| Projects and Grants: | CHE Strategic Scholarships for Frontier Research network for the Joint PhD Program Thai Doctoral Degree, TRF Senior Research Research Scholar RTA 5680006, NHMRC Principal Research Fellowship, CHE Health Cluster SHeP-GMS, KKU award number 156110, TMRC award number P50AI098639, NCI award number R01CA164719, USAMRMC contract number W81XWH-12-C-0267 |
| Date Deposited: | 12 Jun 2018 00:07 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320209 Gastroenterology and hepatology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 50% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920105 Digestive System Disorders @ 80% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 20% |
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