Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico

Vazquez-Prokopec, Gonzalo M., Medina-Berreiro, Anuar, Che-Mendoza, Azael, Dzul-Manzanilla, Felipe, Correa-Morales, Fabian, Guillermo-May, Guillermo, Bibiano-Marín, Wilbert, Uc-Puc, Valentín, Geded-Moreno, Eduardo, Vadillo-Sánchez, José, Palacio-Vargas, Jorge, Ritchie, Scott A., Lenhart, Audrey, and Manrique-Saide, Pablo (2017) Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico. PLoS Neglected Tropical Diseases, 11 (6). e0005656.

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Abstract

The operational impact of deltamethrin resistance on the efficacy of indoor insecticide applications to control Aedes aegypti was evaluated in Merida, Mexico. A randomized controlled trial quantified the efficacy of indoor residual spraying (IRS) against adult Ae. aegypti in houses treated with either deltamethrin (to which local Ae. aegypti expressed a high degree of resistance) or bendiocarb (to which local Ae. aegypti were fully susceptible) as compared to untreated control houses. All adult Ae. aegypti infestation indices during 3 months post-spraying were significantly lower in houses treated with bendiocarb compared to untreated houses (odds ratio < 0.75; incidence rate ratio < 0.65) whereas no statistically significant difference was detected between the untreated and the deltamethrin-treated houses. On average, bendiocarb spraying reduced Ae. aegypti abundance by 60% during a 3-month period. Results demonstrate that vector control efficacy can be significantly compromised when the insecticide resistance status of Ae. aegypti populations is not taken into consideration.

Item ID: 53970
Item Type: Article (Research - C1)
ISSN: 1935-2735
Additional Information:

This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Funders: Emory Global Health Institute (EGHI), Marcus Foundation (MC), Centers for Disease Control and Prevention USA (CDC), CONACYT, Mexico, National Health and Medical Research Council (NHMRC)
Projects and Grants: EGHI and MC project #00052002, CDC: OADS BAA 2016-N-17844, CONACYT project #000000000255141, NHMRC Senior Research Fellowship 1044698
Date Deposited: 11 Jun 2018 23:09
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920404 Disease Distribution and Transmission (incl. Surveillance and Response) @ 50%
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