Allergens and molecular diagnostics of shellfish allergy

Lopata, A.L., Kleine-Tebbe, J., and Kamath, S.D. (2017) Allergens and molecular diagnostics of shellfish allergy. In: Kleine-Tebbe, Jörg, and Jakob, Thilo, (eds.) Molecular Allergy Diagnostics: innovation for a better patient management. Springer, Cham, Switzerland, pp. 399-414.

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Abstract

In recent years, there has been a steady growth in the production and consumption of shellfish due to its important role in human nutrition and health. This increased consumption has led to an increase in adverse health problems among consumers including immunoglobulin E (IgE)-mediated allergic reactions. Approximately 2 % of the world population is affected by shellfish allergy, which includes the crustacean and mollusk groups. The allergenic proteins present in the shellfish group have variable primary structures and often present a challenge in allergen detection and diagnosis. The distinction of crustacean from mollusk is important from clinical point of view, as molecular cross-reactivity, particularly between crustaceans, seems to be determined by the close relationship to insects and mites. Currently, at least seven different shellfish allergens have been identified, mostly from crustaceans; however, only three recombinant allergens are available for IgE-based routine diagnostic, including tropomyosin, arginine kinase, and sarcoplasmic Ca++-binding protein. Other allergens include myosin light chain, troponin C, triose-phosphate isomerase, and actin.

This chapter describes current information on shellfish allergy, the allergenic proteins involved, and diagnostic approaches.

Item ID: 53955
Item Type: Book Chapter (Research - B1)
ISBN: 978-3-319-42498-9
Keywords: skin prick test; myosin light chain; shellfish species; allergenic protein; arginine kinase
Date Deposited: 13 Jun 2018 00:17
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110701 Allergy @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110302 Clinical Chemistry (diagnostics) @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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