Extract-based and molecular diagnostics in fish allergy

Kuehn, A., Radauer, C., Lopata, A.L., Kleine-Tebbe, J., and Swoboda, I. (2017) Extract-based and molecular diagnostics in fish allergy. In: Klein-Tebbe, Jörg, and Jakob, Thilo, (eds.) Molecular Alergy Diagnostics: innovation for a better patient management. Springer, Cham, Switzerland, pp. 381-397.

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Although fish is an elementary component of a healthy diet, it is also a food with high allergenic potential. In most cases, allergic reactions are induced by parvalbumins – small, stable proteins found in the muscle tissue. Many parvalbumin-positive individuals present with clinical reactions to various fish species, which can be explained through cross-reacting IgE antibodies.

Thus far, complete fish extracts and two recombinant parvalbumins are available for IgE-based routine diagnostic procedures. Other important fish allergens are the enolases, the aldolases, and tropomyosin derived from fish muscle and vitellogenin from fish eggs, whose availability for diagnostics would allow more precise analysis of the sensitization profile of a fish-allergic patient. To date, there is no specific immunotherapy for fish allergy available. However, molecular biotechnological approaches have already led to the development of the first hypoallergenic molecules, which offer low-risk therapeutic prospects for the future.

Item ID: 53951
Item Type: Book Chapter (Research - B1)
ISBN: 978-3-319-42498-9
Date Deposited: 13 Jun 2018 00:00
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320506 Medical biochemistry - proteins and peptides (incl. medical proteomics) @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 60%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 100%
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