Progressive decline of cognition during the conversion from prodrome to psychosis with a characteristic pattern of the theory of mind compensated by neurocognition

Zhang, TianHong, Cui, HuiRu, Wei, YanYan, Tang, YingYing, Xu, LiHua, Tang, XiaoChen, Zhu, YiKang, Jiang, LiJuan, Zhang, Bin, Qian, ZhenYing, Chow, Annabelle, Liu, XiaoHua, Li, ChunBo, Xiao, ZePing, and Wang, Jijun (2018) Progressive decline of cognition during the conversion from prodrome to psychosis with a characteristic pattern of the theory of mind compensated by neurocognition. Schizophrenia Research, 195. pp. 554-559.

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Abstract

The association between neurocognition and the theory of mind (ToM) abilities during the progression of psychosis is unclear. This study included 83 individuals with attenuated psychosis syndrome (APS), from which 26 converted to psychosis (converters) after a follow up period of 18 months. Comprehensive cognitive tests (including MATRICS Consensus Cognitive Battery, Faux-Pas Task, and Reading-Mind-in-Eyes Tasks) were administered at baseline. A structural equation modeling (SEM) analysis was conducted to estimate the effects of neurocognition on the ToM functioning in both APS and healthy controls (HC) datasets. At baseline, the converters and non-converters groups differed significantly on several domains of cognitive performance. The SEM analysis demonstrated that the path from neurocognition to ToM was statistically significant in the APS dataset (p < 0.001). However, in the HC dataset, the result of the same analysis was not significant (p = 0.117). Positive correlations between neurocognition and ToM were observed, and the most obvious correlations were found in the converters group compared with the non-converters group (p = 0.064) and compared with the HC group (p = 0.002). The correlation between ToM abilities and neurocognition may be increased during the progression of the condition, especially for individuals who convert to psychosis after a short period.

Item ID: 53889
Item Type: Article (Research - C1)
ISSN: 1573-2509
Keywords: Clinical high risk, Ultra high risk, Transition, Longitudinal, Social cognition
Copyright Information: © 2017 Published by Elsevier B.V.
Funders: National Natural Science Foundation of China (NNSFC), Ministry of Science and Technology of China (MSTC), Shanghai Science and Technology Committee (SSTC), Shanghai Mental Health Center Foundation (SMHCF), Shanghai Key Laboratory of Psychotic Disorders (SKLPD), Division of Early Psychosis (DoEP), Shanghai Jiao Tong University Foundation (SJTUF), Shanghai Shenkang Hospital Development Center (SSHDC), Program of Shanghai Academic Research Leader (PSARL)
Projects and Grants: NNSFC 81671329, NNSFC 81671332, MSTC 2016YFC1306803, SSTC 15411967200, SSTC 14411961400, SMHCF National Key Clinical Disciplines OMA-MH, 2011-873, SKLPD 13dz2260500, DoEP 2013-YJTSZK-05, SJTUF 14JCRY04, SJTUF YG2014MS40, SMHCF 2016-FX-01, SSHDC 16CR2015A, SSHDC 16CR3016A, PSARL 16XD1402400
Date Deposited: 06 Jun 2018 07:50
FoR Codes: 17 PSYCHOLOGY AND COGNITIVE SCIENCES > 1702 Cognitive Science > 170205 Neurocognitive Patterns and Neural Networks @ 100%
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