Zhang, TianHong, Cui, HuiRu, Wei, YanYan, Tang, YingYing, Xu, LiHua, Tang, XiaoChen, Zhu, YiKang, Jiang, LiJuan, Zhang, Bin, Qian, ZhenYing, Chow, Annabelle, Liu, XiaoHua, Li, ChunBo, Xiao, ZePing, and Wang, Jijun (2018) Progressive decline of cognition during the conversion from prodrome to psychosis with a characteristic pattern of the theory of mind compensated by neurocognition. Schizophrenia Research, 195. pp. 554-559.

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Abstract

The association between neurocognition and the theory of mind (ToM) abilities during the progression of psychosis is unclear. This study included 83 individuals with attenuated psychosis syndrome (APS), from which 26 converted to psychosis (converters) after a follow up period of 18 months. Comprehensive cognitive tests (including MATRICS Consensus Cognitive Battery, Faux-Pas Task, and Reading-Mind-in-Eyes Tasks) were administered at baseline. A structural equation modeling (SEM) analysis was conducted to estimate the effects of neurocognition on the ToM functioning in both APS and healthy controls (HC) datasets. At baseline, the converters and non-converters groups differed significantly on several domains of cognitive performance. The SEM analysis demonstrated that the path from neurocognition to ToM was statistically significant in the APS dataset (p < 0.001). However, in the HC dataset, the result of the same analysis was not significant (p = 0.117). Positive correlations between neurocognition and ToM were observed, and the most obvious correlations were found in the converters group compared with the non-converters group (p = 0.064) and compared with the HC group (p = 0.002). The correlation between ToM abilities and neurocognition may be increased during the progression of the condition, especially for individuals who convert to psychosis after a short period.

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