Joone, Carolynne (2017) Porcine zona pellucida immunocontraception in mares. In: Proceedings of the Australian and New Zealand College of Veterinary Scientists Science Week. From: Australian and New Zealand College of Veterinary Scientists Science Week 2018, 6-8 July 2017, Surfers Paradise, QLD, Australia.

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Abstract

Immunocontraceptive vaccines induce an immune response to a hormone or protein critical for normal reproductive function, culminating in infertility. Interest in zona pellucida-based immunocontraception began over forty years ago. The zona pellucida (ZP) is the glycoprotein matrix surrounding the mammalian oocyte and early conceptus. In addition to playing a central role in the binding of spermatozoon and oocyte during fertilization, the ZP functions in the induction of the acrosome reaction, the prevention of polyspermy and protection of the early embryo. In addition, the ZP is intimately involved in communication between an oocyte and its surrounding granulosa cells during follicular development.

Porcine zona pellucida (pZP), derived from porcine ovaries harvested at slaughter, is the most commonly employed form of the vaccine. The immune response generated against pZP, in combination with a suitable adjuvant, cross-reacts with endogenous ZP glycoproteins in treated females. Approximately 80 zoo and wildlife species have been successfully contracepted with this antigen. The primary mechanism of action of pZP immunocontraception has traditionally been thought to involve an antibody-mediated interference with sperm-oocyte binding, thus preventing conception without disrupting oestrous cyclicity. The maintenance of reproductive behaviours has made the pZP vaccine the preferred immunological method of population control in species with complex social structures, such as the feral horse (Equus caballus) and African elephant (Loxodonta africana).

Item ID:	53825
Item Type:	Conference Item (Non-Refereed Research Paper)
Keywords:	horse, contraception, fertility control, anti-Mullerian hormone
Date Deposited:	25 Jul 2018 02:15
FoR Codes:	07 AGRICULTURAL AND VETERINARY SCIENCES > 0702 Animal Production > 070206 Animal Reproduction @ 100%
SEO Codes:	83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8399 Other Animal Production and Animal Primary Products > 839999 Animal Production and Animal Primary Products not elsewhere classified @ 100%
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