Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers

Zhou, Gang, Latchoumanin, Olivier, Hebbard, Lionel, Duan, Wei, Liddle, Christopher, George, Jacob, and Qiao, Liang (2018) Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers. Advanced Drug Delivery Reviews, 134. pp. 107-121.

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Abstract

Traditional anticancer therapies are often unable to completely eradicate the tumor bulk due to multi-drug resistance (MDR) of cancers. A number of mechanisms such as micro-environmental stress and overexpression of drug efflux pumps are involved in the MDR process. Hence, therapeutic strategies for overcoming MDR are urgently needed to improve cancer treatment efficacy. Aptamers are short single-stranded oligonucleotides or peptides exhibiting unique three-dimensional structures and possess several unique advantages over conventional antibodies such as low immunogenicity and stronger tissue-penetration capacity. Aptamers targeting cancer-associated receptors have been explored to selectively deliver a therapeutic cargo (anticancer drugs, siRNAs, miRNAs and drug-carriers) to the intratumoral compartment where they can exert better tumor-killing effects. In this review, we summarize current knowledge of the multiple regulatory mechanisms of MDR, with a particular emphasis on aptamer-mediated novel therapeutic agents and strategies that seek to reversing MDR. The challenges associated with aptamer-based agents and approaches are also discussed.

Item ID: 53769
Item Type: Article (Research - C1)
ISSN: 1872-8294
Keywords: aptamers; cancer; efflux; multi-drug resistance (MDR); mechanisms; therapeutics
Copyright Information: Copyright © 2018 Elsevier B.V. All rights reserved.
Funders: Sydney Medical Foundation (SMF), NSW Cancer Institute Translational Cancer Research Centre, Cancer Council NSW (CC), Cancer Council Queensland (CCQ), James Cook University (JCU)
Projects and Grants: NSW Cancer Institute - grant 15/TRC/1-01, CC APP1070076, CC APP1145008, CC APP1069733, CCQ 1123436, JCU Development Grant 94066
Date Deposited: 02 Oct 2018 02:52
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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