Dose-response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection. A randomized sham controlled trial

Folmli, Brookes, Turman, Bulent, Johnson, Peter, and Abbott, Allan (2018) Dose-response of somatosensory cortex repeated anodal transcranial direct current stimulation on vibrotactile detection. A randomized sham controlled trial. Journal of Neurophysiology, 120 (2). pp. 610-616.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: http://doi.org/10.1152/jn.00926.2017


Abstract

This randomized sham-controlled trial investigated anodal transcranial direct current stimulation (tDCS) over the somatosensory cortex contralateral to hand dominance for dose-response (1 mA, 20 min × 5 days) effects on vibrotactile detection thresholds (VDT). VDT was measured before and after tDCS on days 1, 3, and 5 for low- (30 Hz) and high-frequency (200 Hz) vibrations on the dominant and nondominant hands in 29 healthy adults (mean age = 22.86 yr; 15 men, 14 women). Only the dominant-hand 200-Hz VDT displayed statistically significant medium effect size improvement for mixed-model analysis of variance time-by-group interaction for active tDCS compared with sham. Post hoc contrasts were statistically significant for dominant-hand 200-Hz VDT on day 5 after tDCS compared with day 1 before tDCS, day 1 after tDCS, and day 3 before tDCS. There was a linear dose-response improvement with dominant-hand 200-Hz VDT mean difference decreasing from day 1 before tDCS peaking at −15.5% (SD = 34.9%) on day 5 after tDCS. Both groups showed learning effect trends over time for all VDT test conditions, but only the nondominant-hand 30-Hz VDT was statistically significant (P = 0.03), although post hoc contrasts were nonsignificant after Šidák adjustment. No adverse effects for tDCS were reported. In conclusion, anodal tDCS at 1 mA, 20 min × 5 days on the dominant sensory cortex can modulate a linear improvement of dominant-hand high-frequency VDT but not low-frequency or nondominant-hand VDT.

Item ID: 53757
Item Type: Article (Research - C1)
ISSN: 1522-1598
Funders: Queensland Smart Futures Fellowship, Bond University
Date Deposited: 22 Aug 2018 02:58
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110999 Neurosciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page