Culture results at pancreatic necrosectomy: the microbiology of infected pancreatic necrosis

Coventry, Charles, Palamuthusingam, Pranavan, Neo, Eu Ling, and Vanageti, Venkat (2017) Culture results at pancreatic necrosectomy: the microbiology of infected pancreatic necrosis. Clinics in Surgery, 2. 1396.

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Abstract

Introduction: Necrotizing pancreatitis occurs in 5-10% of patients with acute pancreatitis. Infected pancreatic necrosis (IPN) is a feared complication. Historically, causative organisms were Gramnegative bacteria, but recent international studies now report a predominance of Gram-positive bacteria. Not all the literature is consistent, and there may be regional variation. There is very limited Australian data. This study aims to report causative organisms in IPN in the Australian setting.

Materials and Methods: Retrospective medical record review of all patients who underwent pancreatic necrosectomy at a single centre (tertiary referral center in Adelaide, South Australia) between January 2005 and December 2015. Intraoperative culture specimens were reviewed and the Gram-status and antimicrobial sensitivities noted.

Discussion and Results: A total of 1296 patients were admitted for acute pancreatitis in the study period. 28 patients underwent pancreatic necrosectomy. Mean age 55.71 years (range 30-79), including twenty males and eight females. All patients had intraoperative cultures taken. 20 cultures demonstrated growth. There were 12 Gram-negative isolates (34.3%), 20 Gram-positive isolates (57.1%) and three fungal isolates (8.6%). Two bacterial isolates were antibiotic resistant organisms (one MRSA and one VRE).

Conclusion: The findings were consistent with the majority of recent international studies demonstrating a predominance of Gram-positive organisms.

Item ID: 53613
Item Type: Article (Scholarly Work)
ISSN: 2474-1647
Keywords: infected pancreatic necrosis; pancreatic necrosectomy; necrotizing pancreatitis
Additional Information:

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Date Deposited: 04 Jun 2018 05:17
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110303 Clinical Microbiology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110323 Surgery @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920106 Endocrine Organs and Diseases (excl. Diabetes) @ 80%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures @ 20%
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