A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes

Ojha, Ruchika, Junk, Peter C., Deacon, Glen B., and Bond, Alan M. (2018) A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes. Supramolecular Chemistry, 30 (5-6). pp. 418-424.

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Abstract

A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{(p-BrC6F4)NCH2CH2NEt2}(py)Cl], 1; [Pt{(p-HC6F4)NCH2CH2NEt2}(py)Cl], 2; [Pt{(C6F5)NCH2CH2NEt2}(py)I], 3; [Pt{(p-HC6F4)NCH2CH2NMe2}Cl(py)], 4; [Pt{(C6F5)NCH2CH2NMe2}Cl0.4I0.6(py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds.

Item ID: 53594
Item Type: Article (Research - C1)
ISSN: 1029-0478
Keywords: intermolecular interactions, crystal packing, agostic, hydrogen bonding, platinum(II) complexes
Funders: Australian Government (AG)
Projects and Grants: AG Australian Postgraduate Award
Date Deposited: 09 May 2018 08:36
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030207 Transition Metal Chemistry @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
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