Predictors of longer-term outcome in the Vienna omega-3 high-risk study

Mossaheb, Nilufar, Schaefer, Miriam R., Schlögelhofer, Monika, Klier, Claudia M., Smesny, Stefan, McGorry, Patrick D., Berger, Maximus, and Amminger, G. Paul (2018) Predictors of longer-term outcome in the Vienna omega-3 high-risk study. Schizophrenia Research, 193. pp. 168-172.

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Longer-term data on omega-3 polyunsaturated fatty acids (PUFA) for prevention of psychosis in (ultra high risk) UHR individuals have initially shown promising results.

This analysis aimed to assess clinical predictors of longer-term outcome in UHR individuals treated with omega-3 PUFAs versus placebo.

Data derived from an RCT in 81 UHR individuals treated with omega-3 PUFAs versus placebo for 12 weeks and followup assessment after a median of 6.7 years.

Baseline GAF, baseline PANSS global score, pre-to-post-intervention change in EPA (Eicosapentaenoic acid) level were significant predictors of transition to psychosis, PANSS negative score and baseline MADRS reached trend-levels. In the final multivariate Cox regression analysis change in EPA levels remained the only significant predictor.

Taking into account all other significant predictors, changes in EPA levels were found to be the single-most significant predictor for transition to psychosis in a longer term observation of UHR individuals.

Item ID: 53573
Item Type: Article (Research - C1)
ISSN: 1573-2509
Keywords: Polyunsaturated fatty acids, Fish oil, Prodrome, Ultra-high risk, Psychosis, Outcome
Copyright Information: © 2017 Elsevier B.V. All rights reserved.
Funders: Stanley Medical Research Institute (SMRI), National Health and Medical Research Council (NHMRC), James Cook University (JCU)
Projects and Grants: SMRI grant 03T-315, NHMRC Australia Senior Research Fellowship ID:1080963, NHMRC Senior Principal Research Fellowship ID: 1060996, JCU Postgraduate Research Scholarship
Date Deposited: 09 May 2018 08:22
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320221 Psychiatry (incl. psychotherapy) @ 100%
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