Obesity does not influence prostate intrafractional motion

Brown, Amy, Tan, Alex, Cooper, Scott, and Fielding, Andrew (2018) Obesity does not influence prostate intrafractional motion. Journal of Medical Radiation Sciences, 65 (1). pp. 31-38.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (881kB) | Preview
View at Publisher Website: https://doi.org/10.1002/jmrs.255
 
2
61


Abstract

Introduction: Motion of the prostate is problematic in the accurate delivery of external beam radiation therapy (EBRT) for prostate cancer. This study investigated the relationship between body mass index (BMI), an easily measured indicator of obesity, and prostate motion.

Methods: Prostate motion during EBRT was assessed by measuring the displacement of fiducial markers implanted within the prostate in 130 prostate cancer patients. Interfractional motion was corrected on daily imaging through pre-treatment cone-beam-computed tomography (CBCT) and intrafractional motion measured using movie sequences captured using an electronic portal imaging device (EPID) during treatment delivery.

Results: There was no statistically significant relationship between the mean intrafractional motion and BMI, except in the left-right (LR) translation (P = 0.049) over the study population. For each BMI category, there was no statistical significance (P > 0.05) between any of the translations/rotations except LR (P = 0.003).

Conclusion: While intrafractional motion is an important consideration, prostate motion cannot be reliably predicted through measurement of patient's BMI.

Item ID: 53557
Item Type: Article (Research - C1)
ISSN: 2051-3909
Keywords: interfraction motion, intrafraction motion, obesity, prostate cancer, radiotherapy
Copyright Information: © 2018 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Society of Medical Imaging and Radiation Therapy and New Zealand Institute of Medical Radiation Technology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Funders: THHS Pump Priming Initiative 2013, HP Research Grant (Novice) 2013-2014.
Date Deposited: 09 May 2018 08:10
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111208 Radiation Therapy @ 100%
Downloads: Total: 61
Last 12 Months: 12
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page