Possible association between genetic polymorphisms in transforming growth factor β receptors, serum transforming growth factor β1 concentration and abdominal aortic aneurysm

Golledge, J., Clancy, P., Jones, G.T., Cooper, M., Palmer, L.J., van Rij, A.M., and Norman, P.E. (2009) Possible association between genetic polymorphisms in transforming growth factor β receptors, serum transforming growth factor β1 concentration and abdominal aortic aneurysm. British Journal of Surgery, 96 (6). pp. 628-632.

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Abstract

Background: Previous studies have suggested a role for transforming growth factor (TGF) β and its receptor in thoracic aortic aneurysm, but their role in abdominal aortic aneurysm (AAA) is unknown. This study examined the possible association between TGF-β receptor 1 and 2 (TGFBR-1 and -2) single nucleotide polymorphisms (SNPs) and serum TGF-β1 with AAA.

Methods: Serum concentrations of TGF-β1 and 58 SNPs for TGFBR-1 and -2 were examined in 1003 and 1711 men respectively from the Health In Men Study. Validation of SNPs was examined in a second referral cohort of 1043 subjects from New Zealand, of whom 654 had an AAA.

Results: Serum TGF-β1 was not associated with AAA. Only one SNP in TGFBR-2 was weakly associated with AAA; TGFBR2 g.42917C > T, SNP ID rs1078985CC; odds ratio 0·64 (95 per cent confidence interval (c.i.) 0·45 to 0·93); P = 0·020 uncorrected; but this association did not hold after adjusting for multiple testing and was not validated in the New Zealand cohort: odds ratio 0·98 (95 per cent c.i. 0·50 to 1·94); P = 0·960.

Conclusion: These findings suggest there is no important role of genetic polymorphisms in the main receptors for TGF-β and circulating TGF-β1 in AAA in older individuals.

Item ID: 5347
Item Type: Article (Research - C1)
ISSN: 1365-2168
Date Deposited: 30 Sep 2009 22:32
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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