Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm

Smallwood, L., Warrington, N., Allcock, R., van Bockxmeer, F. , Palmer, L.J., Lacopetta, B., Golledge, J., and Norman, P.E. (2009) Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm. European Journal of Vascular and Endovascular Surgery, 38 (2). pp. 169-171.

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Objective: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA).

Methods: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (1360C > T, and þ649C > T) in men with AAA (nZ678) and in controls (nZ659) was examined using multivariate analyses. The association with AAA expansion (nZ638) was also assessed.

Results: In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected.

Conclusion: MMP2 1360C > T and þ649C > T variants are not risk factors for AAA. ª 2009 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

Item ID: 5345
Item Type: Article (Short Note)
ISSN: 1532-2165
Keywords: abdominal aortic aneurysm; expansion; matrix; metalloproteinase-2; genetic association study
Date Deposited: 01 Oct 2009 01:07
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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