Smallwood, L., Warrington, N., Allcock, R., van Bockxmeer, F. , Palmer, L.J., Lacopetta, B., Golledge, J., and Norman, P.E. (2009) Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm. European Journal of Vascular and Endovascular Surgery, 38 (2). pp. 169-171.

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Abstract

Objective: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA).

Methods: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (1360C > T, and þ649C > T) in men with AAA (nZ678) and in controls (nZ659) was examined using multivariate analyses. The association with AAA expansion (nZ638) was also assessed.

Results: In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected.

Conclusion: MMP2 1360C > T and þ649C > T variants are not risk factors for AAA. ª 2009 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

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