Cytokine responses to acute exercise in healthy older adults: the effect of cardiorespiratory fitness

Windsor, Mark T., Bailey, Tom G., Perissiou, Maria, Meital, Lara, Golledge, Jonathan, Russell, Fraser D., and Askew, Christopher D. (2018) Cytokine responses to acute exercise in healthy older adults: the effect of cardiorespiratory fitness. Frontiers in Physiology, 9. 203.

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Abstract

Markers of chronic inflammation increase with aging, and are associated with cardiovascular disease prevalence and mortality. Increases in fitness with exercise training have been associated with lower circulating concentrations of cytokines known to have pro-inflammatory actions (such as interleukin-6 [IL-6]) and higher circulating concentrations of anti-inflammatory cytokines (interleukin-10 [IL-10]). However, the effect of cardiorespiratory fitness on acute cytokine responses to a single bout of exercise in healthy older individuals is unknown. We compared the response of plasma cytokines IL-6, tumor necrosis factor-alpha (TNF-alpha) and IL-10 to a bout of moderate-intensity continuous and higher-intensity interval exercise between older individuals with higher and lower levels of cardiorespiratory fitness. Sixteen lower-fit (VO2peak: 22.6 +/- 2.8mL. kg(-1).min(-1)) and fourteen higher-fit participants (VO2peak: 37.4 +/- 5.9mL. kg(-1). min(-1)) completed three 24min experimental protocols in a randomized order: (1) moderate-intensity continuous exercise (40% of peak power output [ PPO]); (2) higher-intensity interval exercise (12 x 1 min intervals at 70% PPO separated by 1min periods at 10% PPO); or (3) non-exercise control. Plasma cytokines were measured at rest, immediately after, and during 90 min of recovery following exercise or control. Plasma IL-6 concentrations at baseline were greater in the higher-fit compared to the lower-fit group (P = 0.02), with no difference in plasma IL-10 or TNF-alpha concentrations at baseline between groups. Plasma IL-6 and IL-10 concentrations in both groups increased immediately after all protocols (IL-6: P = 0.02, IL-10: P < 0.01). However, there was no difference in the IL-6 and IL-10 response between the exercise and non-exercise (control) protocols. After all protocols, no changes in plasma TNF-alpha concentrations were observed in either the higher-or lower-fit groups. In this study, basal concentrations of circulating IL-6 were elevated in older individuals with higher levels of cardiorespiratory fitness. However, changes in plasma cytokine concentrations after exercise were not different to changes after non-exercise control in both the lower-and higher-fit groups.

Item ID: 53422
Item Type: Article (Research - C1)
ISSN: 1664-042X
Keywords: inflammation, interleukin-6, interleukin-10, tumor necrosis factor-alpha, aging
Copyright Information: Copyright © 2018 Windsor, Bailey, Perissiou, Meital, Golledge, Russell and Askew. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Funders: National Health and Medical Research Council (NHMRC), The Townsville Hospital, University of Sunshine Coast, Queensland Government
Projects and Grants: NHMRC 1000967, NHMRC 1022752, NHMRC 1079369, NHMRC 1117061
Date Deposited: 03 May 2018 12:03
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1116 Medical Physiology > 111601 Cell Physiology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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