Could mitochondrial dysfunction play a role in manganese toxicity?

Brown, Simon, and Taylor, Nicolas L. (1999) Could mitochondrial dysfunction play a role in manganese toxicity? Environmental Toxicology and Pharmacology, 7 (1). pp. 49-57.

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Individuals suffering from manganese toxicity exhibit several symptoms, including mitochondrial dysfunction, which are similar to those frequently observed in cases of Parkinson’s disease. We review the literature concerning manganese toxicity and mitochondrial function, and propose a simple conceptual model of the aetiology of manganese toxicity which involves an interaction between inhibition of mitochondrial energy transduction, generation of free radicals and mutations of the mitochondrial genome. This conceptual model prompts a number of relatively simple experiments which would provide a test of the model.

Item ID: 53134
Item Type: Article (Research - C1)
ISSN: 1872-7077
Keywords: manganese; toxicity; mitochondria; energy transduction; mutagenesis; free radical
Date Deposited: 24 Jun 2018 23:18
FoR Codes: 06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060107 Enzymes @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111506 Toxicology (incl Clinical Toxicology) @ 50%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 40%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 60%
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