The impact of antimalarial use on the emergence and transmission of Plasmodium falciparum resistance: a scoping review of mathematical models

Brock, Aleish R., Gibbs, Carole A., Voss, Joshua V., and Esterman, Adrian (2017) The impact of antimalarial use on the emergence and transmission of Plasmodium falciparum resistance: a scoping review of mathematical models. Tropical Medicine and Infectious Disease, 2 (4). 54.

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Abstract

The emergence and transmission of resistance to antimalarial treatments continue to hamper malaria elimination efforts. A scoping review was undertaken regarding the impact of antimalarial treatment in the human population on the emergence and transmission of Plasmodium falciparum resistance, to (i) describe the use of mathematical models used to explore this relationship; (ii) discuss model findings; and (iii) identify factors influencing the emergence and transmission of resistance. Search strategies were developed and deployed in six major databases. Thirty-seven articles met the eligibility criteria and were included in the review: nine articles modeled the emergence of resistance, 19 modeled the transmission of resistance, and nine modeled both the emergence and transmission. The proportion of antimalarial use within the population and the presence of residual drug concentrations were identified to be the main predictors of the emergence and transmission of resistance. Influencing factors pertaining to the human, parasite and mosquito populations are discussed. To ensure the prolonged therapeutic usefulness of antimalarial treatments, the effect of antimalarial drug use on the emergence and transmission of resistance must be understood, and mathematical models are a useful tool for exploring these dynamics.

Item ID: 53110
Item Type: Article (Research - C1)
ISSN: 2414-6366
Keywords: scoping review; malaria; Plasmodium falciparum; mathematical model; antimalarial resistance; antimalarial treatment; subtherapeutic; drug quality
Funders: University of South Australia (USA)
Projects and Grants: USA Postgraduate Award
Date Deposited: 12 Apr 2018 01:29
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110899 Medical Microbiology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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